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Title: Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody.
identifier: 1899245
description:
epitope description:fluorescein
host organism:Mus musculus BALB/c
antibody name:4-4-20
aggregation:
instance of dataset
availability:
available
primaryPublications: 15465055
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1019336
landingPage: http://www.iedb.org/assay/1899245
type:
Literature
publicationVenue:
J Mol Biol
dates:
2004
study type: b cell assays
subject species:
fullName:
K S Midelfort
H H Hernandez
S M Lippow
B
C L Drennan
K D Wittrup
method:
binding assay
name:
Substantial energetic improvement with minimal structural perturbation in a high affinity mutant antibody.
description:
The association rate constant of 4-4-20 scFv binding to the epitope conjugate, fluorescein-biotin, was determined by stopped-flow fluorescence measurements.

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