Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1902944 |
| description: |
epitope description:Chain I: S32, P34, N40, T42, L43, E44, V45, T46, E47, Q50; Chain J: N552, A553, C556, G557, Q560, L561, E564
antigen name:Envelope glycoprotein
host organism:Mus musculus BALB/c
antibody name:16F6
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22101933 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022645 |
| landingPage: |
http://www.iedb.org/assay/1902944 |
| type: |
Literature
|
| publicationVenue: |
Nat Struct Mol Biol
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Sudan ebolavirus - Uganda (2000) |
| fullName: |
Joã
o M Dias
Ana I Kuehne
Dafna M Abelson
Shridhar Bale
Anthony C Wong
Peter Halfmann
Majidat A Muhammad
Marnie L Fusco
Samantha E Zak
Eugene Kang
Yoshihiro Kawaoka
Kartik Chandran
John M Dye
Erica Ollmann Saphire
|
| method: |
biological activity
|
| name: |
A shared structural solution for neutralizing ebolaviruses.
|
| description: |
Chain I is GP1 and chain J is GP2. Epitope residues are calculated from the structure [PDB: 3S88] as the antigen residues at 4 Å
distance from the antibody.
The epitope-specific 16F6 mAb neutralized infectious SUDV in the absence of complement in a plaque reduction neutralization assay. MAb 16F6 did not inhibit cathepsin L cleavage of GP1 and did not prevent SUDV GP1,2 attachment to Vero E6 cells. The authors conclude that mAb 16F6 neutralizes SUDV at a post-internalization, non-cathepsin L cleavage step.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
