Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1903647 |
| description: |
epitope description:A: W72, F150, A151; B: T214, R215, F216, A220, S221, K222, C255, Q256, G257, K258, N317, F318, L348, G349, T350, L351, D367, V380, S381, Q382, S383, G384
antigen name:Proprotein convertase subtilisin/kexin type 9
host organism:Mus musculus Xenomouse
antibody name:mAb1
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
19443683 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019641 |
| landingPage: |
http://www.iedb.org/assay/1903647 |
| type: |
Literature
|
| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2009
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Joyce C Y Chan
Derek E Piper
Qiong Cao
Dongming Liu
Chadwick King
Wei Wang
Jie Tang
Qiang Liu
Jared Higbee
Zhen Xia
Yongmei Di
Susan Shetterly
Ziva Arimura
Heather Salomonis
William G Romanow
Stephen T Thibault
Richard Zhang
Ping Cao
Xiao-Ping Yang
Timothy Yu
Mei Lu
Marc W Retter
Gayle Kwon
Kirk Henne
Oscar Pan
Mei-Mei Tsai
Bryna Fuchslocher
Evelyn Yang
Lei Zhou
Ki Jeong Lee
Mark Daris
Jackie Sheng
Yan Wang
Wenyan D Shen
Wen-Chen Yeh
Maurice Emery
Nigel P C Walker
Bei Shan
Margrit Schwarz
Simon M Jackson
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| method: |
biological activity
|
| name: |
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
|
| description: |
Epitope residues are calculated from the structure [PDB: 3H42] as the antigen residues at 4 Å
distance from the antibody. Chains A and B in the structure belong to the same polypeptide chain (Chain A: residues 31-152 constitute the prodomain and Chain B: 153-692
residues 153-454 constitute the catalytic domain, and residues 455-692 constitute the C-terminal domain).
The epitope-specific monoclonal antibody inhibited PCSK9 activity as measured by increased LDLR expression. The monoclonal antibody also inhibited binding of PCSK9 to LDLR.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
