Close-up of the immunogenic alpha1,3-galactose epitope as defined by a monoclonal chimeric immunoglobulin E and human serum using saturation transfer difference (STD) NMR.

Title:

Close-up of the immunogenic alpha1,3-galactose epitope as defined by a monoclonal chimeric immunoglobulin E and human serum using saturation transfer difference (STD) NMR.

Dataset

identifier:	1903775
description:	epitope description:alpha-D-Galp-(1->3)-beta-D-Galp-(1->4)-D-GlcpNAc-yl group host organism:Mus musculus BALB/c GalNAc Transferase null antibody name:M86 scFv-IgE
aggregation:	instance of dataset
availability:	available
primaryPublications:	21990360

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022652
landingPage:	http://www.iedb.org/assay/1903775

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2011

Dimension

study type:	b cell assays
subject species:	Oryctolagus cuniculus

Person

fullName:	Melanie Plum Yvonne Michel Katharina Wallach Tim Raiber Simon Blank Frank I Bantleon Andrea Diethers Kerstin Greunke Ingke Braren Thomas Hackl Bernd Meyer Edzard Spillner

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	Close-up of the immunogenic alpha1,3-galactose epitope as defined by a monoclonal chimeric immunoglobulin E and human serum using saturation transfer difference (STD) NMR.
description:	Epitope-specific antibody bound the epitope conjugated to HSA. NMR analysis revealed the Gal-Gal disaccharide block as crucial for binding with the glycosidic methyl group contributing weakly.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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