Crystal structures of two complexes of the rare-earth-DOTA-binding antibody 2D12.5: ligand generality from a chiral system.

Title:

Crystal structures of two complexes of the rare-earth-DOTA-binding antibody 2D12.5: ligand generality from a chiral system.

identifier:	1903841
description:	epitope description:(S)-2-(4-nitrobenzyl)-DOTA host organism:Mus musculus BALB/c antibody name:2D12.5
aggregation:	instance of dataset
availability:	available
primaryPublications:	14653738

study type:	b cell assays
subject species:

fullName:	Todd M Corneillie Andrew J Fisher Claude F Meares

method:	antigen inhibition

name:	Crystal structures of two complexes of the rare-earth-DOTA-binding antibody 2D12.5: ligand generality from a chiral system.
description:	The affinity of epitope-specific 2D12.5 Fab for DOTA complexed to a yttrium (3+) ion was lower than that for the epitope (S)BAD complexed to a Y (3+) ion, but greater than that for the enantiomer Y-(R)BAD, as shown by competitive ELISA to plate-bound HSA-2IT-Y-BAD.

name:	iedb
homePage:	http://www.iedb.org

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