Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.

Dataset

identifier:	1906756
description:	epitope description:N540 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:AR2A
aggregation:	instance of dataset
availability:	available
primaryPublications:	18064037

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022650
landingPage:	http://www.iedb.org/assay/1906756

Publication

type:	Literature
publicationVenue:	Nat Med
dates:	2008

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus subtype 1a

Person

fullName:	Mansun Law Toshiaki Maruyama Jamie Lewis Erick Giang Alexander W Tarr Zania Stamataki Pablo Gastaminza Francis V Chisari Ian M Jones Robert I Fox Jonathan K Ball Jane A McKeating Norman M Kneteman Dennis R Burton

Data Type

method:	ELISA

Study

name:	Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.
description:	An antibody competition study was performed to determine the binding site of recombinant IgG1 from a patient chronically infected with HCV. Alanine mutagenesis scanning identified the epitope sequence based on the greatest reduction in binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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