Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.

Dataset

identifier:	1906759
description:	epitope description:S424, H488, G523, P525, D535, V538, N540 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:AR3C
aggregation:	instance of dataset
availability:	available
primaryPublications:	18064037

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022650
landingPage:	http://www.iedb.org/assay/1906759

Publication

type:	Literature
publicationVenue:	Nat Med
dates:	2008

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus subtype 1a

Person

fullName:	Mansun Law Toshiaki Maruyama Jamie Lewis Erick Giang Alexander W Tarr Zania Stamataki Pablo Gastaminza Francis V Chisari Ian M Jones Robert I Fox Jonathan K Ball Jane A McKeating Norman M Kneteman Dennis R Burton

Data Type

method:	ELISA

Study

name:	Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge.
description:	An antibody competition study was performed to determine the binding site of recombinant IgG1 from a patient chronically infected with HCV. Alanine mutagenesis scanning identified the epitope sequence based on the greatest reduction in binding. Residues S424, G523, P525, D535, V538 and N540 were identified as being critical for binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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