A comparative analysis of the immunological evolution of antibody 28B4. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

A comparative analysis of the immunological evolution of antibody 28B4.

Dataset

identifier:	1907334
description:	epitope description:5-[(4-nitrobenzyl)(phosphonomethyl)amino]valeric acid host organism:Mus musculus BALB/c antibody name:28B4 germline precursor
aggregation:	instance of dataset
availability:	available
primaryPublications:	11535051

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1008467
landingPage:	http://www.iedb.org/assay/1907334

Publication

type:	Literature
publicationVenue:	Biochemistry
dates:	2001

Dimension

study type:	b cell assays
subject species:

Person

fullName:	J Yin E C Mundorff P L Yang K U Wendt D Hanway R C Stevens P G Schultz

Data Type

method:	surface plasmon resonance (SPR)

Study

name:	A comparative analysis of the immunological evolution of antibody 28B4.
description:	The affinity of the Fab fragment of the germline precursor to catalytic antibody 28B4 for the epitope, a transition state analog, was determined by surface plasmon resonance. The affinity of the germline Fab was 700-fold lower than the affinity-matured 28B4 Fab.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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