Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1907699 |
| description: |
epitope description:V: K74, M107, I109, H112, Q115, I117; W: F43, M44, Y47, Q48, Y51, D89, L92, C130, P132;
antigen name:Vascular endothelial growth factor A (UniProt:P15692)
host organism:Homo sapiens
antibody name:G6
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
16373345 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1002504 |
| landingPage: |
http://www.iedb.org/assay/1907699 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2006
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Germaine Fuh
Ping Wu
Wei-Ching Liang
Mark Ultsch
Chingwei V Lee
Barbara Moffat
Christian Wiesmann
|
| method: |
ELISA
|
| name: |
Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab.
|
| description: |
The functional epitope of G6 Fab on human VEGF was determined by alanine-scanning mutation of h-VEGF. Residues F17, M18, Y21, Q22, Y25, I83, H86, Q89 and I91 were determined to be important for antibody binding.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
