Characterization of an isotype-dependent monoclonal antibody against linear neutralizing epitope effective for prophylaxis of enterovirus 71 infection.

Title:

Characterization of an isotype-dependent monoclonal antibody against linear neutralizing epitope effective for prophylaxis of enterovirus 71 infection.

Dataset

identifier:	1907786
description:	epitope description:RQEKD antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:mAb 51
aggregation:	instance of dataset
availability:	available
primaryPublications:	22279543

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022776
landingPage:	http://www.iedb.org/assay/1907786

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2012

Dimension

study type:	b cell assays
subject species:	Enterovirus A71

Person

fullName:	Xiao Fang Lim Qiang Jia Wei Xin Khong Benedict Yan Balraj Premanand Sylvie Alonso Vincent T K Chow Jimmy Kwang

Data Type

method:	western blot

Study

name:	Characterization of an isotype-dependent monoclonal antibody against linear neutralizing epitope effective for prophylaxis of enterovirus 71 infection.
description:	The epitope-specificity of the mAb was mapped with truncated VP1 proteins to the epitope KQEKD and it was further shown to cross-react with homologous sequences from other enteroviruses. The mAb was not capable of recognizing the mutated epitopes QQEKD and EQEKD.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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