Vaccination with M2e-based multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice.

Title:

Vaccination with M2e-based multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice.

Dataset

identifier:	1908226
description:	epitope description:SLLTEVETPIRNEWG antigen name:Matrix protein 2 host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	22180783

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022672
landingPage:	http://www.iedb.org/assay/1908226

Publication

type:	Literature
publicationVenue:	PLoS One
dates:	2011

Dimension

study type:	b cell assays
subject species:	Influenza A virus (A/Puerto Rico/8/1934(H1N1))

Person

fullName:	Amaya I Wolf Krystyna Mozdzanowska Katie L Williams David Singer Monique Richter Ralf Hoffmann Andrew J Caton Laszlo Otvos Jan Erikson

Data Type

method:	ELISA

Study

name:	Vaccination with M2e-based multiple antigenic peptides: characterization of the B cell response and protection efficacy in inbred and outbred mice.
description:	The M2e epitope-based multiple antigen peptide (MAP) construct induced anti-M2 protein Abs after two immunizations that were amplified with an additional boost. Responses were similar whether the MAP contained Th epitopes CS (381-396) KKIAKMEKASSVFNVV and HBV (19-33) FFLLTRILTIPQSLD or CS (327-345) YLNKIQNSLSTEWSPCSVT and HA (307-319) PKYVKQNTLKLAT. The s.c. route induced significantly higher titers of anti-M2 abs. Abs were also detected in BAL. Responses were negative in C3H, C57BL/6, CD1/CR and Swiss Webster mice.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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