Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1931114 |
| description: |
epitope description:S138, S139, P141, N142, K171, G172, S173, S174, Y175, P176, K177, S179, K180, S181, V183, N211, E260, T262
antigen name:Hemagglutinin
host organism:Homo sapiens
antibody name:del 2D1
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21304166 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1023026 |
| landingPage: |
http://www.iedb.org/assay/1931114 |
| type: |
Literature
|
| publicationVenue: |
MBio
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/South Carolina/1/1918(H1N1)) |
| fullName: |
Jens C Krause
Damian C Ekiert
Terrence M Tumpey
Patricia B Smith
Ian A Wilson
James E Crowe Jr
|
| method: |
biological activity
|
| name: |
An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody.
|
| description: |
The epitope is from the reference: Xu et al. (2010) Science 328: 357-360 [PMID: 20339031].
The epitope-reactive del 2D1 inhibited hemagglutination activity of the 1918 (A/South Carolina/1/1918(H1N1)) and 2009 (A/Mexico/4108/09) pandemic strains, but not against the 2007 seasonal virus (A/Brisbane/59/07). MAb del 2D1 exhibited about 4-fold lower activity than wt 2D1 mAb.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
