Synthetic peptides as functional mimics of a viral discontinuous antigenic site. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Synthetic peptides as functional mimics of a viral discontinuous antigenic site.

Dataset

identifier:	1930527
description:	epitope description:PSQNFGHMHKVVLPPPPPPPPPPCFLMFENVPY + OX(C24) host organism:Cavia porcellus
aggregation:	instance of dataset
availability:	available
primaryPublications:	11851326

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011684
landingPage:	http://www.iedb.org/assay/1930527

Publication

type:	Literature
publicationVenue:	Biologicals
dates:	2001

Dimension

study type:	b cell assays
subject species:

Person

fullName:	J Villé n E Borrà s W M Schaaper R H Meloen M Dá vila E Domingo E Giralt D Andreu

Data Type

method:	in vivo assay

Study

name:	Synthetic peptides as functional mimics of a viral discontinuous antigenic site.
description:	The epitope was designed to mimic discontinuous antigenic site D of FMDV isolate C-S8c1, which encompasses residues from VP1 (Thr193), VP2 (Ser72, Asn74, His79 in the sequence PSQNFGHMHKVVLP), and VP3 (Glu58 in the sequence FLMFENVPY). The epitope D8A, which represents the VP2 and VP3 peptides linked by a polyproline spacer, was disulfide bonded to peptide D8B (CPPPPTG), which mimics the VP1 peptide. One out of three animals immunized with the D8 epitope disulfide hetetodimer was protected against challenge with FMDV, and a second animal developed only minor lesions at 5 days post challenge.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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