Synthetic peptides as functional mimics of a viral discontinuous antigenic site. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Synthetic peptides as functional mimics of a viral discontinuous antigenic site.

Dataset

identifier:	1930529
description:	epitope description:CPPPPTG + SCM(C1) host organism:Bos taurus antibody name:anti-D8
aggregation:	instance of dataset
availability:	available
primaryPublications:	11851326

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1011684
landingPage:	http://www.iedb.org/assay/1930529

Publication

type:	Literature
publicationVenue:	Biologicals
dates:	2001

Dimension

study type:	b cell assays
subject species:

Person

fullName:	J Villé n E Borrà s W M Schaaper R H Meloen M Dá vila E Domingo E Giralt D Andreu

Data Type

method:	cross blocking

Study

name:	Synthetic peptides as functional mimics of a viral discontinuous antigenic site.
description:	The cysteine residue at position 1 was made as the 3-nitro-2-pyridylsulfenyl derivative. The epitope was designed to mimic discontinuous antigenic site D of FMDV isolate C-S8c1, which encompasses residues from VP1 (Thr193), VP2 (Ser72, Asn74, His79 in the sequence PSQNFGHMHKVVLP), and VP3 (Glu58 in the sequence FLMFENVPY). The binding of epitope-reactive anti-D8 sera to FMDV was inhibited by FMDV site D-specific mAbs 5C4 and 2A12, demonstrating the specificity of the anti-D8 sera.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.