Molecular determinants for antibody binding on group 1 house dust mite allergens. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Molecular determinants for antibody binding on group 1 house dust mite allergens.

Dataset

identifier:	1930805
description:	epitope description:R254, Y283, D296 antigen name:Der p 1 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	22210776

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022877
landingPage:	http://www.iedb.org/assay/1930805

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2012

Dimension

study type:	b cell assays
subject species:	Dermatophagoides pteronyssinus

Person

fullName:	Maksymilian Chruszcz Anna Pomé s Jill Glesner Lisa D Vailes Tomasz Osinski Przemyslaw J Porebski Karolina A Majorek Peter W Heymann Thomas A E Platts-Mills Wladek Minor Martin D Chapman

Data Type

method:	ELISA

Study

name:	Molecular determinants for antibody binding on group 1 house dust mite allergens.
description:	The binding of serum IgE from mite-allergic patients to pro-Der p 1 was reduced 20-95% by single amino acid mutations R156A, Y185V or D198A. Pro-Der p 1 inhibited the binding of pooled sera from four donors with the strongest reduction in binding to the mutations. Pro-Der p 1 with mutation R156A, Y185V or D198A were 5- to 10-fold less effective at inhibiting the binding of the serum pool to pro-Der p 1.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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