B cells that produce immunoglobulin E mediate colitis in BALB/c mice. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

B cells that produce immunoglobulin E mediate colitis in BALB/c mice.

Dataset

identifier:	1911166
description:	epitope description:4-(ethoxymethylene)-2-phenyloxazol-5-one host organism:Mus musculus BALB/c
aggregation:	instance of dataset
availability:	available
primaryPublications:	21983080

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022787
landingPage:	http://www.iedb.org/assay/1911166

Publication

type:	Literature
publicationVenue:	Gastroenterology
dates:	2012

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Jennifer C Hoving Frank Kirstein Natalie E Nieuwenhuizen Lizette C E Fick Elias Hobeika Michael Reth Frank Brombacher

Data Type

method:	in vivo assay

Study

name:	B cells that produce immunoglobulin E mediate colitis in BALB/c mice.
description:	Administration of the epitope induced colitis in mice. The use of mice deficient in IgE production or by blocking IgE binding established that the pathogenic factor during epitope induced colitis is IgE. IL-4Ralpha deficient mice were protected against epitope induced disease. Adoptive transfer of IL-4Ralpha+ CD4+ T cells prior to epitope treatment resulted in colitis, demonstrating the role these cells play in disease progression. Adoptive transfer of IL-13 null CD4+ T cells demonstrated that the T cell response is dependent upon IL-13.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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