Immunological Data Discovery Index
Immunological Data Discovery Index
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1022127 |
| landingPage: |
http://www.iedb.org/assay/1911177 |
| type: |
Literature
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| publicationVenue: |
J Mol Biol
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| dates: |
2007
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| study type: | b cell assays |
| subject species: | Human immunodeficiency virus 1 |
| fullName: |
Rosa M F Cardoso
Florence M Brunel
Sharon Ferguson
Michael Zwick
Dennis R Burton
Philip E Dawson
Ian A Wilson
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| method: |
surface plasmon resonance (SPR)
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| name: |
Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10.
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| description: |
The affinity of epitope-specific antibody 4E10 for the 104-2 peptide was determined by SPR. Residue R7 of peptide 104-2 is an ornithine. The side chains of ornithine and cysteine at position 4 are covalently linked to form a cyclic peptide. The thioether bridge constrained the peptide to adopt an alpha-helical conformation.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
