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Title: Structure of an antibody in complex with its mucin domain linear epitope that is protective against Ebola virus.
identifier: 1917071
description:
epitope description:GKLGLITNTIAGVAGLI
antigen name:Envelope glycoprotein
host organism:Mus musculus BALB/c
antibody name:14G7
aggregation:
instance of dataset
availability:
available
primaryPublications: 22171276
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1022810
landingPage: http://www.iedb.org/assay/1917071
type:
Literature
publicationVenue:
J Virol
dates:
2012
study type: b cell assays
subject species: Zaire ebolavirus
fullName:
Daniel Olal
Ana I Kuehne
Shridhar Bale
Peter Halfmann
Takao Hashiguchi
Marnie L Fusco
Jeffrey E Lee
Liam B King
Yoshihiro Kawaoka
John M Dye Jr
Erica Ollmann Saphire
method:
x-ray crystallography
name:
Structure of an antibody in complex with its mucin domain linear epitope that is protective against Ebola virus.
description:
The Fab-peptide complex was crystallized and the structure was determined by molecular replacement. Mutagenesis of the the central region of the epitope revealed that Thr-485 is critical for binding, and can only be replaced by serine.

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