Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1917096 |
| description: |
epitope description:C118, V119, L121, V196, T198, Q199, A200, R406, R406, I407, K408, Q409, I410, M421, P424
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:17b
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
15893666 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1019669 |
| landingPage: |
http://www.iedb.org/assay/1917096 |
| type: |
Literature
|
| publicationVenue: |
Structure
|
| dates: |
2005
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus type 1 (isolate YU2) |
| fullName: |
Chih-chin Huang
Franç
ois Stricher
Loï
c Martin
Julie M Decker
Shahzad Majeed
Philippe Barthe
Wayne A Hendrickson
James Robinson
Christian Roumestand
Joseph Sodroski
Richard Wyatt
George M Shaw
Claudio Vita
Peter D Kwong
|
| method: |
x-ray crystallography
|
| name: |
Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth.
|
| description: |
Epitope residues are calculated from the structure [PDB: 1YYM] (same epitope is for [PDB: 1YYL]) as the antigen residues at 4 Å
distance from the antibody.
The epitope of Fab 17b on HIV-1 gp120 was determined from the crystal structure of the ternary complex of Fab17b bound to gp120 core in complex with CD4M33, a construct with CD4 residues transplanted onto a scorpion-toxin scaffold. The deglycosylated gp120 core protein studied had Gly-Ala-Gly tri-peptide substitutions for the V1/V2 and V3 loop regions. There are no direct CD4M33-Fab 17b contacts.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
