Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesis.

Title:

Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesis.

identifier:	1927561
description:	epitope description:D306, N308, N310 antigen name:Protein-glutamine gamma-glutamyltransferase 2 host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	19878304

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Ró bert Kirá ly Eva Csosz Tibor Kurtá n Sá ndor Antus Krisztiá n Szigeti Zsó fia Simon-Vecsei Ilma Rita Korponay-Szabó Zsolt Keresztessy Lá szló Fé sü s

method:	ELISA

name:	Functional significance of five noncanonical Ca2+-binding sites of human transglutaminase 2 characterized by site-directed mutagenesis.
description:	Mutation of the epitope residues (D306N, N308S, N310S) affected IgA binding weakly, with aproximately 79% remaining average binding, in a panel of celiac disease patients' sera.

name:	iedb
homePage:	http://www.iedb.org

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