Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1927564 |
| description: |
epitope description:E560, Q563, H564, L565, Q567, L568, W571, G572, K574, Q575, L576, R579, M629, D632, N636, S640, H643, I646, E647, V570, I573, K574, Q577
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:8066
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21085615 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022192 |
| landingPage: |
http://www.iedb.org/assay/1927564 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2010
|
| study type: | b cell assays |
| subject species: | Human immunodeficiency virus 1 |
| fullName: |
Elena Gustchina
Mi Li
John M Louis
D Eric Anderson
John Lloyd
Christian Frisch
Carole A Bewley
Alla Gustchina
Alexander Wlodawer
G Marius Clore
|
| method: |
x-ray crystallography
|
| name: |
Structural basis of HIV-1 neutralization by affinity matured Fabs directed against the internal trimeric coiled-coil of gp41.
|
| description: |
The epitope of Fab 8066 on the 5-Helix construct, an inner core mimetic of gp41, was determined from the crystal structure of the complex. The 5-Helix construct comprises a single chain in which the N-heptad repeat (HR) trimeric coiled-coil is surrounded by only two C-heptad repeats helices, thereby exposing one face of the internal trimeric N-HR coiled-coil.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
