Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies.

Title:

Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies.

identifier:	1927509
description:	epitope description:H633, Y636, E637, E640, Q643, K644, E647, K648, Q651 antigen name:Envelope glycoprotein gp160 host organism:Homo sapiens antibody name:1281
aggregation:	instance of dataset
availability:	available
primaryPublications:	21076402

study type:	b cell assays
subject species:	HIV-1 M:A

fullName:	Gary Frey Jia Chen Sophia Rits-Volloch Michael M Freeman Susan Zolla-Pazner Bing Chen

method:	surface plasmon resonance (SPR)

name:	Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies.
description:	Epitope residues are calculated from the structure [PDB: 3P30] as the antigen residues at 4 Å distance from the antibody. The epitope-specific mAb 1281 bound preferentially to the construct gp41-post versus gp41-inter, as determined by surface plasmon resonance. The antigen gp41-post is a construct to capture a gp41 conformation that exists only when membrane fusion is complete (six-helix conformation with partial MPER (membrane proximal external region)). In comparison, the antigen gp41-inter is a construct to capture a gp41 conformation that exists in a fusion-intermediate state.

name:	iedb
homePage:	http://www.iedb.org

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