Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope.

Title:

Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope.

identifier:	1927721
description:	epitope description:NWFDITNWLWYIR antigen name:Envelope glycoprotein gp160 host organism:Oryctolagus cuniculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	20826338

study type:	b cell assays
subject species:	Human immunodeficiency virus 1

fullName:	Bruno E Correia Yih-En Andrew Ban Margaret A Holmes Hengyu Xu Katharine Ellingson Zane Kraft Chris Carrico Erica Boni D Noah Sather Camille Zenobia Katherine Y Burke Tyler Bradley-Hewitt Jessica F Bruhn-Johannsen Oleksandr Kalyuzhniy David Baker Roland K Strong Leonidas Stamatatos William R Schief

method:	antigen inhibition

name:	Computational design of epitope-scaffolds allows induction of antibodies specific for a poorly immunogenic HIV vaccine epitope.
description:	The epitope inhibited the binding of the antiserum to HIV-1 HXB2 gp41. Antiserum from two rabbits also bound directly to the 4E10 epitope peptide. Alanine substitution of Trp, Phe, Asp, Ile or Leu at positions 2, 3, 4, 5 and 9, respectively, significantly reduced avidity of the antisera for the epitope.

name:	iedb
homePage:	http://www.iedb.org

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