DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid beta-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease.

Title:

DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid beta-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease.

Dataset

identifier:	1927808
description:	epitope description:DAEFRHDSGYE antigen name:Amyloid beta A4 protein host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	22248819

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022789
landingPage:	http://www.iedb.org/assay/1927808

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2012

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Purevdorj B Olkhanud Mohammed Mughal Koichi Ayukawa Enkhzol Malchinkhuu Monica Bodogai Neil Feldman Sarah Rothman Jong-Hwan Lee Srinivasulu Chigurupati Eitan Okun Kunio Nagashima Mark P Mattson Arya Biragyn

Data Type

method:	ELISA

Study

name:	DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid beta-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease.
description:	The response was similar in both young (4 months) and old (12-15 months), and in wild type and 3XTgAd mice. IgG2b was the most prominent isotype with less IgG1 and very low levels of IgG2a.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

Feedback?

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.