Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1927813 |
| description: |
epitope description:H564, L565, Q567, L568, T569, W571, G572, K574, Q575, A578, R579, H643, V570, I573, K574, Q577
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:HK20
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21124990 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022158 |
| landingPage: |
http://www.iedb.org/assay/1927813 |
| type: |
Literature
|
| publicationVenue: |
PLoS Pathog
|
| dates: |
2010
|
| study type: | b cell assays |
| subject species: | HIV-1 M:B_HXB2R |
| fullName: |
Charles Sabin
Davide Corti
Victor Buzon
Mike S Seaman
David Lutje Hulsik
Andreas Hinz
Fabrizia Vanzetta
Gloria Agatic
Chiara Silacci
Lara Mainetti
Gabriella Scarlatti
Federica Sallusto
Robin Weiss
Antonio Lanzavecchia
Winfried Weissenhorn
|
| method: |
biological activity
|
| name: |
Crystal structure and size-dependent neutralization properties of HK20, a human monoclonal antibody binding to the highly conserved heptad repeat 1 of gp41.
|
| description: |
Epitope residues are calculated from the structure [PDB: 2XRA] as the antigen residues at 4 Å
distance from the antibody.
The epitope-specific HK20 IgG, Fab and scFv neutralized HIV-1 Tier-1 and Tier-2 isolates spanning 6 clades, using either TZM-b1 or HOS.CD4-R5 as target cells.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
