Evaluation of novel Streptococcus pyogenes vaccine candidates incorporating multiple conserved sequences from the C-repeat region of the M-protein.

Title:

Evaluation of novel Streptococcus pyogenes vaccine candidates incorporating multiple conserved sequences from the C-repeat region of the M-protein.

Dataset

identifier:	1927895
description:	epitope description:ASREAKKKVEADLAASREAKKQVEKALEASREAKKKVEADLAASREAKKQVEKALE host organism:Mus musculus B10.BR
aggregation:	instance of dataset
availability:	available
primaryPublications:	22265945

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022848
landingPage:	http://www.iedb.org/assay/1927895

Publication

type:	Literature
publicationVenue:	Vaccine
dates:	2012

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Michelle J Bauer Melina M Georgousakis Therese Vu Anna Henningham Andreas Hofmann Mandy Rettel Louise M Hafner Kadaba S Sriprakash David J McMillan

Data Type

method:	flow cytometry

Study

name:	Evaluation of novel Streptococcus pyogenes vaccine candidates incorporating multiple conserved sequences from the C-repeat region of the M-protein.
description:	The epitope is a chimera of two M protein variant sequences: ASREAKKQVEKALE and ASREAKKKVEADLA. Sera from mice immunized with the chimera containing two variant sequence from the S. pyogenes M protein were reactive with cells infected with S. pyogenes M1, 88-30 and ES-61.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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