Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1928129 |
| description: |
epitope description:C119, V120, L122, V200, T202, Q203, A204, C205, R419, K421, Q422, I423, M434, P437
antigen name:Envelope glycoprotein gp160
host organism:Homo sapiens
antibody name:17b
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
17301785 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022128 |
| landingPage: |
http://www.iedb.org/assay/1928129 |
| type: |
Literature
|
| publicationVenue: |
Nature
|
| dates: |
2007
|
| study type: | b cell assays |
| subject species: | HIV-1 M:B_HXB2R |
| fullName: |
Tongqing Zhou
Ling Xu
Barna Dey
Ann J Hessell
Donald Van Ryk
Shi-Hua Xiang
Xinzhen Yang
Mei-Yun Zhang
Michael B Zwick
James Arthos
Dennis R Burton
Dimiter S Dimitrov
Joseph Sodroski
Richard Wyatt
Gary J Nabel
Peter D Kwong
|
| method: |
surface plasmon resonance (SPR)
|
| name: |
Structural definition of a conserved neutralization epitope on HIV-1 gp120.
|
| description: |
The epitope residues are calculated from the PDB structures [PDB: PDB 2NXY, 2NXZ, 2NY0, 2NY1, 2NY2, 2NY3, 2NY4, 2NY5, 2NY6] as antigen residues at 4Å
distance from the antibody.
Binding of the epitope-specific monoclonal antibody 17b to the wt HIV gp120 core and to variants constrained to stay in the CD4-bound conformation was measured by surface-plasmon resonance. The gp120 core protein had Gly-Ala-Gly tri-peptide substitutions for the V1/V2 and V3 loop regions.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
