Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta.

Title:

Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta.

Dataset

identifier:	1928157
description:	epitope description:VFFAEDVGSN antigen name:Amyloid beta A4 protein host organism:Homo sapiens antibody name:gantenerumab
aggregation:	instance of dataset
availability:	available
primaryPublications:	21955818

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022723
landingPage:	http://www.iedb.org/assay/1928157

Publication

type:	Literature
publicationVenue:	J Alzheimers Dis
dates:	2012

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Bernd Bohrmann Karlheinz Baumann Jö rg Benz Francoise Gerber Walter Huber Fré dé ric Knoflach Jü rg Messer Krisztina Oroszlan Robert Rauchenberger Wolfgang F Richter Christine Rothe Margit Urban Michael Bardroff Michael Winter Christer Nordstedt Hansruedi Loetscher

Data Type

method:	western blot

Study

name:	Gantenerumab: a novel human anti-Abeta antibody demonstrates sustained cerebral amyloid-beta binding and elicits cell-mediated removal of human amyloid-beta.
description:	The reactivity of gantenerumab was analyzed with by pepspot assay of 43 overlapping decapeptides spanning the N-terminal region of Aß42. Gantenerumab showed strong reactivity with peptides EFRHDSGYEV and AEFRHDSGYE at the N-terminus, and the epitope (VFFAEDVGSN) within the central part of Aß.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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