Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections.

Title:

Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections.

identifier:	1929234
description:	epitope description:NPVENYIDSVLNEVLVVPNIQ antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	22121050

study type:	b cell assays
subject species:	Human rhinovirus A89

fullName:	Katarzyna Niespodziana Kamila Napora Clarissa Cabauatan Margarete Focke-Tejkl Walter Keller Verena Niederberger Maria Tsolia Ioannis Christodoulou Nikolaos G Papadopoulos Rudolf Valenta

method:	ELISA

name:	Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections.
description:	The epitope was mapped to an N-terminal 20mer peptide in VP1 which becomes exposed on intact RV only when it docks to its receptor ICAM 1. Molecular modeling using the 3-dimensional RV capsid structures revealed that the epitope is localized inside the capsid and outside the areas involved in receptor binding or RV neutralization. Therefore, the authors suggest misdirection antibody responses against a nonprotective epitope as a mechanism how RV escapes immunity and causes recurrent infections.

name:	iedb
homePage:	http://www.iedb.org

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