A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.

Title:

A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.

identifier:	1929794
description:	epitope description:P134, S137, K177, Y180, T183 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:65C6
aggregation:	instance of dataset
availability:	available
primaryPublications:	22238297

study type:	b cell assays
subject species:	H5N1 subtype

fullName:	Hongxing Hu Jarrod Voss Guoliang Zhang Philippi Buchy Teng Zuo Lulan Wang Feng Wang Fan Zhou Guiqing Wang Cheguo Tsai Lesley Calder Steve J Gamblin Linqi Zhang Vincent Deubel Boping Zhou John J Skehel Paul Zhou

method:	biological activity

name:	A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.
description:	This set of residues is found conserved among all the (sub)clades of the H5N1 subtype except for subclade 7.2 (such as A/Chicken/Vietnam/NCVD-016/08) where Serine 121 is subsituted with Tyrosine. The ability of the epitope specific mAb to neutralize pseudotyped lentiviral infection of cells was assessed. Mutation of each epitope residue (P118, S121, K161, Y164, T167) of this strain generated variants more resistant to neutralization than the WT pseudovirus.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.