A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.

Title:

A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.

identifier:	1929800
description:	epitope description:P134, S137, K177, Y180, T183 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:65C6
aggregation:	instance of dataset
availability:	available
primaryPublications:	22238297

study type:	b cell assays
subject species:	H5N1 subtype

fullName:	Hongxing Hu Jarrod Voss Guoliang Zhang Philippi Buchy Teng Zuo Lulan Wang Feng Wang Fan Zhou Guiqing Wang Cheguo Tsai Lesley Calder Steve J Gamblin Linqi Zhang Vincent Deubel Boping Zhou John J Skehel Paul Zhou

method:	electron microscopy

name:	A human antibody recognizing a conserved epitope of H5 hemagglutinin broadly neutralizes highly pathogenic avian influenza H5N1 viruses.
description:	This set of residues is found conserved among all the (sub)clades of the H5N1 subtype except for subclade 7.2 (such as A/Chicken/Vietnam/NCVD-016/08) where Serine 121 is subsituted with Tyrosine. The ability of the epitope-specific Fab to bind HA by EM was analyzed. The binding was shown to occur at the membrane-distal tip of HA.

name:	iedb
homePage:	http://www.iedb.org

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