Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the beta-sheet structure of MIF.

Title:

Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the beta-sheet structure of MIF.

Dataset

identifier:	1938250
description:	epitope description:FGGSSEPCALCSLHSIGKI antigen name:Macrophage migration inhibitory factor host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	22238348

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022899
landingPage:	http://www.iedb.org/assay/1938250

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2012

Dimension

study type:	b cell assays
subject species:	Homo sapiens

Person

fullName:	Randolf J Kerschbaumer Manfred Rieger Dirk Vö lkel Didier Le Roy Thierry Roger Jurate Garbaraviciene Wolf-Henning Boehncke Jü rgen Mü llberg Rene M Hoet Clive R Wood Gerhard Antoine Michael Thiele Helga Savidis-Dacho Michael Dockal Hartmut Ehrlich Thierry Calandra Friedrich Scheiflinger

Data Type

method:	in vivo assay

Study

name:	Neutralization of macrophage migration inhibitory factor (MIF) by fully human antibodies correlates with their specificity for the beta-sheet structure of MIF.
description:	The epitope sequence was deduced. Administration of the epitope-specific antibody significantly reduced TNFalpha and IL-6 levels released in the endotoxic shock model.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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