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Title: Natural anti-A and anti-B of the ABO system: allo- and autoantibodies have different epitope specificity.
identifier: 1939141
description:
epitope description:alpha-D-Galp-(1->3)-[alpha-L-Fucp-(1->2)]-D-Galp
antigen name:glycoprotein
host organism:Homo sapiens
aggregation:
instance of dataset
availability:
available
primaryPublications: 21981750
authorizations:
registration not required
accessURL: http://www.iedb.org/reference/1022990
landingPage: http://www.iedb.org/assay/1939141
type:
Literature
publicationVenue:
Transfusion
dates:
2012
study type: b cell assays
subject species: Homo sapiens
fullName:
Polina Obukhova
Elena Korchagina
Stephen Henry
Nicolai Bovin
method:
ELISA
name:
Natural anti-A and anti-B of the ABO system: allo- and autoantibodies have different epitope specificity.
description:
The epitope is the terminal trisaccharide from blood group B antigen, and is shared among the three type B antigens.
Epitope-specific human Abs (IgG + IgM + IgA) isolated by affinity purification from blood type A donors reacted with the B type 3 tetrasaccharide strongly. By immuno-depletion, it was shown that the reactivity is solely based on the presence of the antibodies against the epitope. A low but detectable reactivity was found in B blood type sera, but by immuno-affinity and immuno-depletion studies, it was found to depend on the cross-reactivity of anti-A antibodies with B-type antigens.

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