Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1931364 |
| description: |
epitope description:HA1: E341; HA2: E360, G361, I363, D364, R370, E375, T377, G378, Q379, A380, A381, L383, N491, E495 + GLYC(2:N499)
antigen name:Hemagglutinin
host organism:Homo sapiens
antibody name:CR8020
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| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21737702 |
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1022349 |
| landingPage: |
http://www.iedb.org/assay/1931364 |
| type: |
Literature
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| publicationVenue: |
Science
|
| dates: |
2011
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| study type: | b cell assays |
| subject species: | Influenza A virus (A/Hong Kong/1/1968(H3N2)) |
| fullName: |
Damian C Ekiert
Robert H E Friesen
Gira Bhabha
Ted Kwaks
Mandy Jongeneelen
Wenli Yu
Carla Ophorst
Freek Cox
Hans J W M Korse
Boerries Brandenburg
Ronald Vogels
Just P J Brakenhoff
Ronald Kompier
Martin H Koldijk
Lisette A H M Cornelissen
Leo L M Poon
Malik Peiris
Wouter Koudstaal
Ian A Wilson
Jaap Goudsmit
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| method: |
bio-layer interferometry assay
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| name: |
A highly conserved neutralizing epitope on group 2 influenza A viruses.
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| description: |
The epitope specific Fab CR8020 bound to hemmagglutin from the influenza virus, as well as to HAs (H3,H4, H7, H10, H14, H15) from other group 2 subtype viruses, but did not bind to HAs (H1, H5, H6 H9, H13, H16) from group 1 subtype influenza viruses. KD's were determined by bio-layer interferometry, which is conceptually similar to surface plasmon resonance.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |
