Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses.

Title:

Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses.

identifier:	1931177
description:	epitope description:DAEFRHDSGYE antigen name:Amyloid beta A4 protein host organism:Mus musculus C57BL/6
aggregation:	instance of dataset
availability:	available
primaryPublications:	22301697

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Hayk Davtyan Anahit Ghochikyan Nina Movsesyan Barry Ellefsen Irina Petrushina David H Cribbs Drew Hannaman Claire F Evans Michael G Agadjanyan

method:	ELISA

name:	Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses.
description:	Immunization of mice with the DepVac vaccine using either electroporation (EP) i.m. or gene gun (GG) intradermal delivery induced a strong anti-Aß response. EP-mediated vaccination induced predominantly IgG2a isotype antibodies (IgG1/IgG2a = 0.61), whereas GG vaccination induced predominantly IgG1 isotype antibodies (IgG1/IgG2a = 11.87). The antisera bound to monomer, oligomeric and fibrillar Aß42 peptide by dot blotting.

name:	iedb
homePage:	http://www.iedb.org

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