Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1931351 |
| description: |
epitope description:HA1: E341; HA2: E360, G361, I363, D364, R370, E375, T377, G378, Q379, A380, A381, L383, N491, E495 + GLYC(2:N499)
antigen name:Hemagglutinin
host organism:Homo sapiens
antibody name:CR8020
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
21737702 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022349 |
| landingPage: |
http://www.iedb.org/assay/1931351 |
| type: |
Literature
|
| publicationVenue: |
Science
|
| dates: |
2011
|
| study type: | b cell assays |
| subject species: | Influenza A virus (A/Hong Kong/1/1968(H3N2)) |
| fullName: |
Damian C Ekiert
Robert H E Friesen
Gira Bhabha
Ted Kwaks
Mandy Jongeneelen
Wenli Yu
Carla Ophorst
Freek Cox
Hans J W M Korse
Boerries Brandenburg
Ronald Vogels
Just P J Brakenhoff
Ronald Kompier
Martin H Koldijk
Lisette A H M Cornelissen
Leo L M Poon
Malik Peiris
Wouter Koudstaal
Ian A Wilson
Jaap Goudsmit
|
| method: |
biological activity
|
| name: |
A highly conserved neutralizing epitope on group 2 influenza A viruses.
|
| description: |
The epitope specific mAb CR8020 neutralized the influenza virus, as well as other group 2 subtype viruses (H3,H4, H7, H10), but did not neutralize group 1 subtype influenza viruses, as shown by an in vitro microneutralization assay. Mutants D19N and G33E, also selected as Escape mutants selected with CR8020 carried mutation D19N or G33E, confirming their contribution to the epitope.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
