Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity.

Title:

Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity.

identifier:	1936189
description:	epitope description:K310, A313, E314, T315, Q316, H317, L321, I352, A354, E368 antigen name:Genome polyprotein host organism:Mus musculus BALB/c antibody name:2H12
aggregation:	instance of dataset
availability:	available
primaryPublications:	22491255

study type:	b cell assays
subject species:	Dengue virus type 1 Hawaii

fullName:	Claire M Midgley Aleksandra Flanagan Hai Bac Tran Wanwisa Dejnirattisai Kriangkrai Chawansuntati Amonrat Jumnainsong Wiyada Wongwiwat Thaneeya Duangchinda Juthathip Mongkolsapaya Jonathan M Grimes Gavin R Screaton

method:	ELISA

name:	Structural analysis of a dengue cross-reactive antibody complexed with envelope domain III reveals the molecular basis of cross-reactivity.
description:	The epitope-specific mAb 2H12 reacted the live virus by ELISA and with the virus from the supernatant of Den4-infected cells by Western blot. MAb 2H12 showed the strongest binding to Dengue virus serotype 1 followed by serotype 4. Binding to serotypes 2 and 3 did not reach saturation.

name:	iedb
homePage:	http://www.iedb.org

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