Molecular recognition of Candida albicans (1->2)-beta-mannan oligosaccharides by a protective monoclonal antibody reveals the immunodominance of internal saccharide residues.

Title:

Molecular recognition of Candida albicans (1->2)-beta-mannan oligosaccharides by a protective monoclonal antibody reveals the immunodominance of internal saccharide residues.

Dataset

identifier:	1942990
description:	epitope description:4-deoxy-beta-D-mannopyranosyl-(1->2)-beta-D-mannopyranosyl-(1->2)-beta-D-mannopyranosyl group host organism:Mus musculus BALB/cByJ antibody name:C3.1
aggregation:	instance of dataset
availability:	available
primaryPublications:	22493450

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1024406
landingPage:	http://www.iedb.org/assay/1942990

Publication

type:	Literature
publicationVenue:	J Biol Chem
dates:	2012

Dimension

study type:	b cell assays
subject species:

Person

fullName:	Margaret A Johnson Jonathan Cartmell Nina E Weisser Robert J Woods David R Bundle

Data Type

method:	nuclear magnetic resonance (NMR)

Study

name:	Molecular recognition of Candida albicans (1->2)-beta-mannan oligosaccharides by a protective monoclonal antibody reveals the immunodominance of internal saccharide residues.
description:	The STDD-NMR and Tr-NOESY experiments of the epitope-mAb complex showed the strongest enhancements in the mannose residue adjacent to the reducing-end residue, which implies that the mAb binds in a frame-shifted mode when compared to the natural trisaccharide epitope.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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