Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.

Dataset

identifier:	1943003
description:	epitope description:T416, N417, P484, Y485, V538, N540, G547, W549 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:AR1A
aggregation:	instance of dataset
availability:	available
primaryPublications:	22492964

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1023049
landingPage:	http://www.iedb.org/assay/1943003

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2012

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus subtype 1a

Person

fullName:	Erick Giang Marcus Dorner Jannick C Prentoe Marlè ne Dreux Matthew J Evans Jens Bukh Charles M Rice Alexander Ploss Dennis R Burton Mansun Law

Data Type

method:	ELISA

Study

name:	Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.
description:	The epitope sequence was provided in cited reference Law et al. Nature Medicine 2008 14:25-27 [PMID:18064037]. The apparent affinity of the epitope-specific mAb was tested against lectin-captured E1E2 antigen. This mAb was also shown to block the binding of the E1E2 complex to CD81.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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