Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.

Title:

Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.

identifier:	1939572
description:	epitope description:LEKDEREQLRILGEKEAKLAQQSQALQELISELD antigen name:E3 ubiquitin-protein ligase TRIM21 host organism:Mus musculus BALB/c antibody name:7.2H4, 7.8C7, 7.8H4, 7.9D3
aggregation:	instance of dataset
availability:	available
primaryPublications:	22084395

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Auré lie Ambrosi Vijole Dzikaite Jeongsook Park Linn Strandberg Vijay K Kuchroo Eric Herlenius Marie Wahren-Herlenius

method:	ELISA

name:	Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.
description:	Four out of 6 mAbs tested were directed to the epitope. Fine specificity determination with multiple- and single-residue mutant peptides showed that they were all sensitive to the combined mutations E208Q, E213N, and E227K, were all insensitive to mutation D233A and were heterogeneous in their reactivity to combined mutations E201V, E204L and E215V.

name:	iedb
homePage:	http://www.iedb.org

If you are having problems using our tools, or if you would just like to send us some feedback, please post your questions on Feedback.