Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.

Title:

Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.

identifier:	1939576
description:	epitope description:LEKDEREQLRILGEKEAKLAQQSQALQELISELD antigen name:E3 ubiquitin-protein ligase TRIM21 host organism:Mus musculus BALB/c antibody name:7.8C7
aggregation:	instance of dataset
availability:	available
primaryPublications:	22084395

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Auré lie Ambrosi Vijole Dzikaite Jeongsook Park Linn Strandberg Vijay K Kuchroo Eric Herlenius Marie Wahren-Herlenius

method:	biological activity

name:	Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.
description:	Addition of epitope-specific mAb to spontaneously oscillating primarily cultured neonatal cardiomyocytes altered the frequency of calcium oscillations and induced progressive intracellular calcium accumulation.

name:	iedb
homePage:	http://www.iedb.org

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