Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitis C virus E2 protein confer noninterfering, additive neutralization.

Title:

Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitis C virus E2 protein confer noninterfering, additive neutralization.

Dataset

identifier:	1939865
description:	epitope description:NTGWLAGLFYQHK antigen name:Genome polyprotein host organism:Homo sapiens
aggregation:	instance of dataset
availability:	available
primaryPublications:	22171278

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1022801
landingPage:	http://www.iedb.org/assay/1939865

Publication

type:	Literature
publicationVenue:	J Virol
dates:	2012

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Alexander W Tarr Richard A Urbanowicz Dhanya Jayaraj Richard J P Brown Jane A McKeating William L Irving Jonathan K Ball

Data Type

method:	biological activity

Study

name:	Naturally occurring antibodies that recognize linear epitopes in the amino terminus of the hepatitis C virus E2 protein confer noninterfering, additive neutralization.
description:	Epitope-affinity-purified sera neutralized HCV pseudo-particles expressing HCV strain H77c E2 protein, and a chimeric HCV strain JFH-1 virus expressing E2 from strain H77c. Additive neutralization was seen when sera purified against another epitope was added.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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