Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions. |
| authorizations: |
registration not required
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| accessURL: |
http://www.iedb.org/reference/1023099 |
| landingPage: |
http://www.iedb.org/assay/1939901 |
| type: |
Literature
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| publicationVenue: |
Proc Natl Acad Sci U S A
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Dengue virus 1 Nauru/West Pac/1974 |
| fullName: |
Ruklanthi de Alwis
Scott A Smith
Nicholas P Olivarez
William B Messer
Jeremy P Huynh
Wahala M P B Wahala
Laura J White
Michael S Diamond
Ralph S Baric
James E Crowe Jr
Aravinda M de Silva
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| method: |
biological activity
|
| name: |
Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions.
|
| description: |
The discontinuous epitope residues are located in the DI and DI-DII hinge regions of the Dengue virus 1 WP 74 envelope protein.
The epitope-specific mAb was shown to neutralize homologous DENV, but not DENV2-4. The epitopic residues were mapped by sequence analysis of viral escape mutants. Binding was not observed to recombinant E protein, EDIII, nor premembrane protein, suggesting the epitope is preserved only on full viral particles.
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| name: |
iedb
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| homePage: |
http://www.iedb.org |