Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions.

Dataset

identifier:	1939910
description:	epitope description:R228 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:2D22
aggregation:	instance of dataset
availability:	available
primaryPublications:	22499787

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1023099
landingPage:	http://www.iedb.org/assay/1939910

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2012

Dimension

study type:	b cell assays
subject species:	Dengue virus 2 S-16803

Person

fullName:	Ruklanthi de Alwis Scott A Smith Nicholas P Olivarez William B Messer Jeremy P Huynh Wahala M P B Wahala Laura J White Michael S Diamond Ralph S Baric James E Crowe Jr Aravinda M de Silva

Data Type

method:	ELISA

Study

name:	Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions.
description:	The discontinuous epitope residue is located in the DII region of the Dengue virus 2 S-16803 envelope protein. The epitope-specific mAb bound to DENV2 in ELISA. The epitopic residue was mapped by sequence analysis of viral escape mutants.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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