The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus.

Title:

The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus.

identifier:	1943176
description:	epitope description:I132, I133, P134, W138, S139, Y180, T183 antigen name:Hemagglutinin host organism:Homo sapiens antibody name:AVFluIgG01
aggregation:	instance of dataset
availability:	available
primaryPublications:	22662275

study type:	b cell assays
subject species:	H5N1 subtype

fullName:	Zhiliang Cao Jiazi Meng Xingxing Li Ruiping Wu Yanxin Huang Yuxian He

method:	biological activity

name:	The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus.
description:	The epitope-specific mAb efficiently blocked both virus-receptor binding and post-attachment steps, while its Fab fragment exerts the post-attachment inhibition only. The mAb could also inhibit HA-mediated cell-cell membrane fusion at a dose-dependent manner and block the acquisition of pH-induced protease sensitivity.

name:	iedb
homePage:	http://www.iedb.org

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