Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus. | ImmuneData Discovery Index

Immunological Data Discovery Index

Immunological Data Discovery Index

Title:

Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.

Dataset

identifier:	1943130
description:	epitope description:R639, D698 antigen name:Genome polyprotein host organism:Homo sapiens antibody name:AR4A, AR5A
aggregation:	instance of dataset
availability:	available
primaryPublications:	22492964

Access

authorizations:	registration not required
accessURL:	http://www.iedb.org/reference/1023049
landingPage:	http://www.iedb.org/assay/1943130

Publication

type:	Literature
publicationVenue:	Proc Natl Acad Sci U S A
dates:	2012

Dimension

study type:	b cell assays
subject species:	Hepatitis C virus (isolate H77)

Person

fullName:	Erick Giang Marcus Dorner Jannick C Prentoe Marlè ne Dreux Matthew J Evans Jens Bukh Charles M Rice Alexander Ploss Dennis R Burton Mansun Law

Data Type

method:	ELISA

Study

name:	Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus.
description:	The epitope-specific mAb was shown to bind the E1E2 complex in native form, but not after it was reduced, suggesting a conformational epitope. This was confirmed with mutational analysis using alanine-scanning which showed residues R639 and D698 to be critical for binding.

Data Repository

name:	iedb
homePage:	http://www.iedb.org

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