The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus.

Title:

The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus.

identifier:	1943183
description:	epitope description:ATYTTDAQSYHM host organism:Homo sapiens antibody name:AVFluIgG01
aggregation:	instance of dataset
availability:	available
primaryPublications:	22662275

study type:	b cell assays
subject species:

fullName:	Zhiliang Cao Jiazi Meng Xingxing Li Ruiping Wu Yanxin Huang Yuxian He

method:	phage display

name:	The epitope and neutralization mechanism of AVFluIgG01, a broad-reactive human monoclonal antibody against H5N1 influenza virus.
description:	Attempts to map the epitope specificity of the mAb were made using mimotopes from a random peptide phage display library. No consensus sequences or common sequence motifs were found in the selected mimotopes that could be used to deduce the epitopic HA residues. The epitope specificity of the mAb was therefore determined with mutagenesis.

name:	iedb
homePage:	http://www.iedb.org

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