Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner.

Title:

Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner.

identifier:	1943238
description:	epitope description:RRSILPYGDSMDRIEKDRLQ antigen name:Collagen alpha-1(XVII) chain host organism:Oryctolagus cuniculus
aggregation:	instance of dataset
availability:	available
primaryPublications:	22523387

study type:	b cell assays
subject species:	Homo sapiens

fullName:	Ken Natsuga Wataru Nishie Satoru Shinkuma Hideyuki Ujiie Machiko Nishimura Daisuke Sawamura Hiroshi Shimizu

method:	in vivo assay

name:	Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner.
description:	Adoptive transfer of epitope affinity purified antibodies did not induce skin detachment, a model of bullous pemphigoid, in neonatal COL17-humanized mice.

name:	iedb
homePage:	http://www.iedb.org

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