Immunological Data Discovery Index
Immunological Data Discovery Index
| identifier: | 1940197 |
| description: |
epitope description:S585, F586, K587, L588, E589, K590, E591, V592, Q603, K605, E607, E642, K643, P644, L667, K668, L669, S670, W671
antigen name:Genome polyprotein
host organism:Mus musculus BALB/c
antibody name:4E11
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| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22285214 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1024470 |
| landingPage: |
http://www.iedb.org/assay/1940197 |
| type: |
Literature
|
| publicationVenue: |
Structure
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Dengue virus type 1 FGA/89 |
| fullName: |
Joseph J B Cockburn
M Erika Navarro Sanchez
Nickolas Fretes
Agathe Urvoas
Isabelle Staropoli
Carlos M Kikuti
Lark L Coffey
Fernando Arenzana Seisdedos
Hugues Bedouelle
Felix A Rey
|
| method: |
x-ray crystallography
|
| name: |
Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody.
|
| description: |
The epitope of scFV 4E11 on domain III of Dengue virus 1 envelope protein was determined from the crystal structure of the complex, solved by molecular replacement. The complexes of scFv 4E11 with DIII from each of the four DENV isolates, serotype 1 [PDB: 3UZQ], serotype 2 [PDB: 3UZV], serotype 3 [PDB: 3UZE], serotype 4 [PDB: 3UYP], have a very similar overall structure. The residues in both paratope and epitope have very similar conformations in all four complexes, showing that 4E11 cross-reactivity does not involve a significant induced fit.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |
