Immunological Data Discovery Index
Immunological Data Discovery Index
| Title: | Protein modification by deamidation indicates variations in joint extracellular matrix turnover. |
| identifier: | 1940568 |
| description: |
epitope description:TFLKNTVMEC + DEAM(N64)
antigen name:Cartilage oligomeric matrix protein
host organism:Mus musculus
antibody name:6-1A10, 6-3B3, 6-3B1, 6-3A1, 6-1G7, 6-1H12, 6-1H7, 6-2A9, 6-1A12, 6-1A6, 6-1A8, 6-1A4, 6-1F9, 6-1B4, 6-3B5, 6-1H3, 6-3A5, 6-3B10, 6-1F8, 6-1H1, 6-1C12
|
| aggregation: |
instance of dataset
|
| availability: |
available
|
| primaryPublications: |
22179616 |
| authorizations: |
registration not required
|
| accessURL: |
http://www.iedb.org/reference/1022794 |
| landingPage: |
http://www.iedb.org/assay/1940568 |
| type: |
Literature
|
| publicationVenue: |
J Biol Chem
|
| dates: |
2012
|
| study type: | b cell assays |
| subject species: | Homo sapiens |
| fullName: |
Jonathan B Catterall
Ming F Hsueh
Thomas V Stabler
Christopher R McCudden
Michael Bolognesi
Robert Zura
Joanne M Jordan
Jordan B Renner
Sheng Feng
Virginia B Kraus
|
| method: |
ELISA
|
| name: |
Protein modification by deamidation indicates variations in joint extracellular matrix turnover.
|
| description: |
The epitope is the deaminated version (TFLKDTVMEC) of the natural sequence TFLKNTVMEC. The deamidation is predicted to occur naturally in the cartilage.
Out of 21 mAbs obtained after immunization with the epitope, 13 were found to be specific for the epitope in its deaminated form while 8 were reactive to both the deaminated epitope and the natural Asn64-containing variant peptide.
|
| name: |
iedb
|
| homePage: |
http://www.iedb.org |